Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults.

ABSTRACT: The prevalence of age-related cognitive disorders/dementia is increasing, and effective prevention and treatment interventions are lacking due to an incomplete understanding of aging neuropathophysiology. Emerging evidence suggests that abnormalities in gut microbiome are linked with age-related cognitive decline and getting acceptance as one of the pillars of the Geroscience hypothesis. However, the potential clinical importance of gut microbiome abnormalities in predicting the risk of cognitive decline in older adults is unclear. Till now the majority of clinical studies were done using 16S rRNA sequencing which only accounts for analyzing bacterial abundance, while lacking an understanding of other crucial microbial kingdoms, such as viruses, fungi, archaea, and the functional profiling

SUBMITTER: Chaudhari DS 

PROVIDER: S-EPMC10643725 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature