Inhibitory neuron map of sevoflurane induced neurotoxicity model in young primates.

ABSTRACT:

Introduction

Sevoflurane, one of the most commonly used anesthetic agents in children, may induce neuronal dysfunction and cognitive impairment. Exposure to sevoflurane might induce an imbalance between neural excitation and inhibition which could be a mechanism behind anesthesia-induced cognitive and affective dysfunctions. However, the underlying mechanisms remain unclear.

Methods

In this study, we used two rhesus macaques in the control group, and one rhesus macaques in the anesthesia group. We employed single-nucleus RNA sequencing (snRNA-seq) technology to explore alterations in distinct types of inhibitory neurons involved in the long-term cognitive impairment caused by sevoflurane in young macaques.

Results

Following sevoflurane treatment, an upregulation was o

SUBMITTER: Niu Y 

PROVIDER: S-EPMC10643782 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature