Targeted metabolomics reveals plasma biomarkers and metabolic alterations of the aging process in healthy young and older adults.

ABSTRACT: With the exponential growth in the older population in the coming years, many studies have aimed to further investigate potential biomarkers associated with the aging process and its incumbent morbidities. Age is the largest risk factor for chronic disease, likely due to younger individuals possessing more competent adaptive metabolic networks that result in overall health and homeostasis. With aging, physiological alterations occur throughout the metabolic system that contribute to functional decline. In this cross-sectional analysis, a targeted metabolomic approach was applied to investigate the plasma metabolome of young (21-40y; n = 75) and older adults (65y + ; n = 76). A corrected general linear model (GLM) was generated, with covariates of gender, BMI, and chronic condition score (C

SUBMITTER: Jasbi P 

PROVIDER: S-EPMC10643785 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature