Clinical significance of DNA damage response mutations in stage I and stage IIIa NSCLC.

ABSTRACT:

Background

DNA damage response (DDR) pathways are essential to sustain genomic stability and play a critical role in cancer development and progression. Here, we investigated the profile of DDR gene mutations in early-stage non-small cell lung cancer (NSCLC) and their prognostic values.

Methods

We first examined 74 DDR genes involved in seven DDR pathways and then focused on six specific genes: ATM, BRCA1, BRCA2, CHEK1, BARD1, and BRIP1. A total of 179 stage I and IIIa NSCLC patients who received curative resection in Peking Union Medical College Hospital and their corresponding samples were collected for DNA sequencing, immunohistochemistry and survival analysis.

Results

A total of 167 eligible patients were finally analyzed. Mutation frequencies were 82% and 26.3% f

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10643798 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature