Basal autophagic flux measured in blood correlates positively with age in adults at increased risk of type 2 diabetes.

ABSTRACT: Preclinical data show that autophagy delays age-related disease. It has been postulated that age-related disease is-at least in part-caused by an age-related decline in autophagy. However, autophagic flux has never been measured in humans across a spectrum of aging in a physiologically relevant context. To address this critical gap in knowledge, the objective of this cross-sectional observational study was to measure basal autophagic flux in whole blood taken from people at elevated risk of developing type 2 diabetes and correlate it with chronological age. During this study, 119 people were recruited and five people were excluded during sample analysis such that 114 people were included in the final analysis. Basal autophagic flux measured in blood and correlations with parameters such as

SUBMITTER: Bensalem J 

PROVIDER: S-EPMC10643809 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature