Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.

ABSTRACT: Respiratory influenza A virus (IAV) infection continues to pose significant challenges in healthcare of human diseases including asthma. IAV infection in mice was shown to increase IL-33, a key cytokine in driving airway inflammation in asthma, but how IL-33 is regulated during viral infection remains unclear. We previously found that a genetic mutation in Toll-interacting protein (Tollip) was linked to less airway epithelial Tollip expression, increased neutrophil chemokines, and lower lung function in asthma patients. As Tollip is involved in maintaining mitochondrial function, and mitochondrial stress may contribute to extracellular ATP release and IL-33 secretion, we hypothesized that Tollip downregulates IL-33 secretion via inhibiting ATP release during IAV infection. Wild-type and To

SUBMITTER: Schaunaman N 

PROVIDER: S-EPMC10643888 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature