CLIPA7 Exhibits Pleiotropic Roles in the Anopheles gambiae Immune Response.

ABSTRACT: Clip domain serine proteases and clip domain serine protease homologs (cSPHs) are key components of serine protease cascades that drive the melanization response. Despite lacking catalytic activity, cSPHs play essential roles in regulating melanization, but the spectrum of functions they catalyze within and outside these cascades is not fully understood. Aside from their classical role as cofactors for PPO activation, we have previously revealed an unprecedented complexity in the function and molecular organization of these cSPHs in the immune response of the malaria vector Anopheles gambiae. Here, we add yet another dimension to the complex roles underpinning the contributions of cSPHs to mosquito immunity by showing that CLIPA7, a member of the expanded cSPH family, defines a novel branc

SUBMITTER: Zakhia R 

PROVIDER: S-EPMC10643895 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature