A circadian clock gene-related signature for predicting prognosis and its association with sorafenib response in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), one of the highest causes of cancer-associated death, has effective treatments, especially for patients with advanced HCC. Circadian rhythm participates in several important physiological functions, and its chronic disruption results in many disordered diseases, including cancer. However, the role of circadian rhythm in the overall survival (OS) of patients with HCC remains unclear.

Methods

We investigated the expression, copy number variation (CNV), and mutation profiles of core circadian clock genes in normal and tumor tissues. We developed and validated a messenger RNA signature (mRNASig) based on prognostic circadian clock genes. A set of bioinformatic tools were applied for functional annotation and tumor-associated microenviro

SUBMITTER: Liang Q 

PROVIDER: S-EPMC10643945 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature