Assessing the Genomic Landscape of Cervical Cancers: Clinical Opportunities and Therapeutic Targets.

ABSTRACT:

Purpose

Tumor genomic profiling is increasingly used to guide treatment strategy in patients with cancer. We integrated tumor genomic, clinical demographic, and treatment response data to assess how prospective tumor-normal sequencing impacted treatment selection in patients with cervical cancer.

Experimental design

Cervical cancers were prospectively analyzed using the MSK-IMPACT (Memorial Sloan Kettering Cancer Center - Integrated Mutation Profiling of Actionable Cancer Targets) next-generation sequencing panel. Clinical data, including histology, stage at diagnosis, treatment history, clinical trial enrollment and outcomes, date of last follow-up, and survival status were obtained from medical records.

Results

A total of 177 patients with cervical cancer (squamous,

SUBMITTER: Friedman CF 

PROVIDER: S-EPMC10644000 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature