Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan.

ABSTRACT:

Importance

Estimating absolute risk of lung cancer for never-smoking individuals is important to inform lung cancer screening programs.

Objectives

To integrate data on environmental tobacco smoke (ETS), a known lung cancer risk factor, with a polygenic risk score (PRS) that captures overall genetic susceptibility, to estimate the absolute risk of lung adenocarcinoma (LUAD) among never-smokers in Taiwan.

Design, setting, and participants

The analyses were conducted in never-smoking women in the Taiwan Genetic Epidemiology Study of Lung Adenocarcinoma, a case-control study. Participants were recruited between September 17, 2002, and March 30, 2011. Data analysis was performed from January 17 to July 15, 2022.

Exposures

A PRS was derived using 25 genetic variants

SUBMITTER: Blechter B 

PROVIDER: S-EPMC10644212 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature