Pathological Networking of Gray Matter Dendritic Density With Classic Brain Morphometries in OCD.

ABSTRACT:

Importance

The pathogenesis of obsessive-compulsive disorder (OCD) may involve altered dendritic morphology, but in vivo imaging of neurite morphology in OCD remains limited. Such changes must be interpreted functionally within the context of the multimodal neuroimaging approach to OCD.

Objective

To examine whether dendritic morphology is altered in patients with OCD compared with healthy controls (HCs) and whether such alterations are associated with other brain structural metrics in pathological networks.

Design, setting, and participants

This case-control study used cross-sectional data, including multimodal brain images and clinical symptom assessments, from 108 patients with OCD and 108 HCs from 2014 to 2017. Patients with OCD were recruited from Shanghai Mental

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10644219 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature