Torsemide vs Furosemide Among Patients With New-Onset vs Worsening Chronic Heart Failure: A Substudy of the TRANSFORM-HF Randomized Clinical Trial.

ABSTRACT:

Importance

Differences in clinical profiles, outcomes, and diuretic treatment effects may exist between patients with de novo heart failure (HF) and worsening chronic HF (WHF).

Objectives

To compare clinical characteristics and treatment outcomes of torsemide vs furosemide in patients hospitalized with de novo HF vs WHF.

Design, setting, and participants

All patients with a documented ejection fraction who were randomized in the Torsemide Comparison With Furosemide for Management of Heart Failure (TRANSFORM-HF) trial, conducted from June 18 through March 2022, were included in this post hoc analysis. Study data were analyzed March to May 2023.

Exposure

Patients were categorized by HF type and further divided by loop diuretic strategy.

Main outcomes and measu

SUBMITTER: Krim SR 

PROVIDER: S-EPMC10644243 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature