SARS-CoV-2 Virologic Rebound With Nirmatrelvir-Ritonavir Therapy : An Observational Study.

ABSTRACT:

Background

Data are conflicting regarding an association between treatment of acute COVID-19 with nirmatrelvir-ritonavir (N-R) and virologic rebound (VR).

Objective

To compare the frequency of VR in patients with and without N-R treatment for acute COVID-19.

Design

Observational cohort study.

Setting

Multicenter health care system in Boston, Massachusetts.

Participants

Ambulatory adults with acute COVID-19 with and without use of N-R.

Intervention

Receipt of 5 days of N-R treatment versus no COVID-19 therapy.

Measurements

The primary outcome was VR, defined as either a positive SARS-CoV-2 viral culture result after a prior negative result or 2 consecutive viral loads above 4.0 log₁₀ copies/mL that were also at least 1.0 log₁

SUBMITTER: Edelstein GE 

PROVIDER: S-EPMC10644265 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature