Total body bone mineral density and various spinal disorders: a Mendelian randomization study.

ABSTRACT:

Introduction

Observational studies have yielded inconsistent findings regarding the correlation between bone mineral density (BMD) and various spinal disorders. To explore the relationship between total-body BMD and various spinal disorders further, we conducted a Mendelian randomization analysis to assess this association.

Methods

Two-sample bidirectional Mendelian randomization (MR) analysis was employed to investigate the association between total-body BMD and various spinal disorders. The inverse-variance weighted (IVW) method was used as the primary effect estimate, and additional methods, including weighted median, MR-Egger, simple mode, and weighted mode, were used to assess the reliability of the results. To examine the robustness of the data further, we conducted a

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC10644298 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature