Association between genetically predicted rheumatoid arthritis and alopecia areata: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Although numerous observational studies have indicated a potential association between autoimmune diseases, such as rheumatoid arthritis (RA) and alopecia areata (AA), the research reports lack a clear causal relationship. In this study, our objective is to utilize the Mendelian randomization (MR) design to examine the potential causal association between RA and AA.

Methods

To investigate the causal relationship between RA and AA, we utilized large-scale gene aggregation data from genome-wide association studies (GWAS), including RA (n=58,284) and AA (n=361,822) based on previous observational studies. In our analysis, we mainly employed the inverse variance-weighted (IVW) method of the random effects model, supplemented by the weighted median (WM) method and the

SUBMITTER: Zhong S 

PROVIDER: S-EPMC10644376 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature