CHOP upregulation and dysregulation of the mature form of the SNAT2 amino acid transporter in the placentas from small for gestational age newborns.

ABSTRACT:

Background

The placentas from newborns that are small for gestational age (SGA; birth weight < -2 SD for gestational age) may display multiple pathological characteristics. A key determinant of fetal growth and, therefore, birth weight is placental amino acid transport, which is under the control of the serine/threonine kinase mechanistic target of rapamycin (mTOR). The effects of endoplasmic reticulum (ER) stress on the mTOR pathway and the levels of amino acid transporters are not well established.

Methods

Placentas from SGA and appropriate for gestational age (AGA) newborns and the human placental BeWo cell line exposed to the ER stressor tunicamycin were used.

Results

We detected a significant increase in the levels of C/EBP homologous protein (CHOP) in the placen

SUBMITTER: Barroso E 

PROVIDER: S-EPMC10644500 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature