Oncogenic activation revealed by FGFR2 genetic alterations in intrahepatic cholangiocarcinomas.

ABSTRACT:

Background

Except for gene fusions, FGFR2 genetic alterations in intrahepatic cholangiocarcinomas (ICCs) have received limited attention, leaving patients harboring activating FGFR2 gene mutations with inadequate access to targeted therapies.

Experimental design

We sought to survey FGFR2 genetic alterations in ICC and pan-cancers using fluorescence in situ hybridization and next-generation sequencing. We conducted an analysis of the clinical and pathological features of ICCs with different FGFR2 alterations, compared FGFR2 lesion spectrum through public databases and multicenter data, and performed cellular experiments to investigate the oncogenic potential of different FGFR2 mutants.

Results

FGFR2 gene fusions were identified in 30 out of 474 ICC samples, while five

SUBMITTER: Pu X 

PROVIDER: S-EPMC10644541 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature