Grid2 interacting protein is a potential biomarker related to immune infiltration in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is one of the three deadliest malignant tumors in the world, posing a severe hazard to human health. Nonetheless, the 5-year survival rate for advanced CRC remains unsatisfactory. Grid2 interacting protein (GRID2IP) is a Purkinje fiber postsynaptic scaffold protein implicated in a number of signal transduction pathways in the nervous system. Previous studies have shown that Grid2 is closely related to the occurrence and prognosis of gastric cancer and many other diseases. Therefore, we aim to identify the relationship between GRID2IP and the occurrence and prognosis of CRC.

Methods

Transcriptome data were retrieved from The Cancer Genome Atlas (TCGA) database to analyze the differential expression of GRID2IP in a variety of malignant tumors

SUBMITTER: Zhao J 

PROVIDER: S-EPMC10644545 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature