Construction of iron metabolism-related prognostic features of gastric cancer based on RNA sequencing and TCGA database.

ABSTRACT:

Background

Researches have manifested that the disorder of iron metabolism is participated in Gastric cancer (GC), but whether iron metabolism-relevant genes (IMRGs) is related to the survival outcome of GC remain unknown.

Methods

Eleven tumor as well as nine adjacent normal tissues from GC patients were underwent mRNA sequencing, and the The Cancer Genome Atlas Stomach Cancer (TCGA-STAD) datasets were acquired from the TCGA database. Cox analyses and least absolute shrinkage and selection operator (LASSO) regression were applied to build a IMRGs signature. The relationship between signature genes and the infiltration profiling of 24 immune cells were investigated using single-sample GSEA (ssGSEA). Meanwhile, the potential biological significance, genes that act synergistica

SUBMITTER: Liu X 

PROVIDER: S-EPMC10644585 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature