Sex-based differences in natural killer T cell-mediated protection against diet-induced steatohepatitis in Balb/c mice.

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in Western countries, evolving into metabolic dysfunction-associated steatohepatitis (MASH) with a sexual dimorphism. Fertile women exhibit lower MASLD risk than men, which diminishes post-menopause. While NKT-cell involvement in steatohepatitis is debated, discrepancies may stem from varied mouse strains used, predominantly C57BL6/J with Th1-dominant responses. Exploration of steatohepatitis, encompassing both genders, using Balb/c background, with Th2-dominant immune response, and CD1d-deficient mice in the Balb/c background (lacking Type I and Type II NKT cells) can clarify gender disparities and NKT-cell influence on MASH progression. A high fat and choline-deficient (HFCD) diet was used in male and female mi

SUBMITTER: Cuno-Gomiz C 

PROVIDER: S-EPMC10644614 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature