Is the Urinary and Gut Microbiome Associated With Bladder Cancer?

ABSTRACT:

Background

Microbiome dysbiosis plays a role in the pathogenesis of many urological diseases, including bladder cancer (BC). The aim of the study was to compare the urinary and gut microbiota of patients with BC with a healthy control (HC) group.

Methods

The study group included patients hospitalized in 2020 to 2021 with diagnosed BC and HC. Prior to the transurethral resection of bladder tumor, patients collected their urine and stool which was then subjected to 16S rRNA gene sequencing.

Results

Overall, 25 patients were enrolled in the study: 18 in the BC group and 7 in the HC group. Analysis of the urine and stool microbiome showed no statistically significant differences between patients with BC and HC in alpha diversity, beta diversity, and difference in taxa rel

SUBMITTER: Chorbinska J 

PROVIDER: S-EPMC10644734 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature