Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study.

ABSTRACT:

Background

Estrogens play a critical role in parturition, and poly- and perfluoroalkyl substances (PFAS), which have estrogenic effects, have been associated with preterm birth. However, the impact of estrogens on the association between PFAS and preterm birth is unknown.

Objective

The objective of this study is to investigate if estrogens modified the association between PFAS and preterm birth, using a nested case-control study design.

Methods

A total of 371 preterm births and 508 controls were selected from a birth cohort study in China between 2016 and 2018. Perfluorobutanoic acid (PFBA), perfluorohexanesulfonic acid (PFHxS) and its branched isomer, perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and its branched isomer, and perfluorononanoic aci

SUBMITTER: Qin XD 

PROVIDER: S-EPMC10644897 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature