Assignment of molecular origins of NOE signal at -3.5 ppm in the brain.

ABSTRACT:

Purpose

Nuclear Overhauser enhancemen mediated saturation transfer effect, termed NOE (-3.5 ppm), is a major source of CEST MRI contrasts at 3.5 ppm in the brain. Previous phantom experiments have demonstrated that both proteins and lipids, two major components in tissues, have substantial contributions to NOE (-3.5 ppm) signals. Their relative contributions in tissues are informative for the interpretation of NOE (-3.5 ppm) contrasts that could provide potential imaging biomarkers for relevant diseases, which remain incompletely understood.

Methods

Experiments on homogenates and supernatants of brain tissues collected from healthy rats, that could isolate proteins from lipids, were performed to evaluate the relative contribution of lipids to NOE (-3.5 ppm) signals. On the o

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10644915 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature