Use of Multi-Site Radiation Therapy for Systemic Disease Control.

ABSTRACT: Metastatic cancer is a heterogeneous entity, some of which could benefit from local consolidative radiation therapy (RT). Although randomized evidence is growing in support of using RT for oligometastatic disease, a highly active area of investigation relates to whether RT could benefit patients with polymetastatic disease. This article highlights the preclinical and clinical rationale for using RT for polymetastatic disease, proposes an exploratory framework for selecting patients best suited for these types of treatments, and briefly reviews potential challenges. The goal of this hypothesis-generating review is to address personalized multimodality systemic treatment for patients with metastatic cancer. The rationale for using high-dose RT is primarily for local control and immune activa

SUBMITTER: Patel RR 

PROVIDER: S-EPMC10644952 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature