Sarcomeric gene variants among Indians with hypertrophic cardiomyopathy: A scoping review.

ABSTRACT: Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease that frequently causes sudden cardiac death (SCD) among young adults. Several pathogenic mutations in genes encoding the cardiac sarcomere have been identified as diagnostic factors for HCM and proposed as prognostic markers for SCD. The objective of this review was to determine the scope of available literature on the variants encoding sarcomere proteins associated with SCD reported among Indian patients with HCM. The eligibility criteria for the scoping review included full text articles that reported the results of genetic screening for sarcomeric gene mutations in HCM patients of Indian south Asian ancestry. We systematically reviewed studies from the databases of Medline, Scopus, Web of Science core collection and Goo

SUBMITTER: Koshy L 

PROVIDER: S-EPMC10645028 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature