Blood Purification for Adult Patients With Severe Infection or Sepsis/Septic Shock: A Network Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Objectives

This study aimed to conduct a comprehensive and updated systematic review with network meta-analysis (NMA) to assess the outcome benefits of various blood purification modalities for adult patients with severe infection or sepsis.

Data sources

We conducted a search of PubMed, MEDLINE, clinical trial registries, Cochrane Library, and Embase databases with no language restrictions.

Study selection

Only randomized controlled trials (RCTs) were selected.

Data extraction

The primary outcome was overall mortality. The secondary outcomes were the length of mechanical ventilation (MV) days and ICU stay, incidence of acute kidney injury (AKI), and kidney replacement therapy requirement.

Data synthesis

We included a total of 60 RCTs with 4,595 participa

SUBMITTER: Chen JJ 

PROVIDER: S-EPMC10645104 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature