Plasma Nitric Oxide Consumption Is Elevated and Associated With Adverse Outcomes in Critically Ill Patients.

ABSTRACT:

Objectives

Impaired nitric oxide (NO) bioavailability may contribute to microvascular dysfunction in sepsis. Excessive plasma NO consumption has been attributed to scavenging by circulating cell-free hemoglobin. This may be a mechanism for NO deficiency in sepsis and critical illness. We hypothesized that plasma NO consumption is high in critically ill patients, particularly those with sepsis, acute respiratory distress syndrome (ARDS), shock, and in hospital nonsurvivors. We further hypothesized that plasma NO consumption is correlated with plasma cell-free hemoglobin concentration.

Design

Retrospective cohort study.

Setting

Adult ICUs of an academic medical center.

Patients and subjects

Three hundred sixty-two critically ill patients and 46 healthy control su

SUBMITTER: Dony CA 

PROVIDER: S-EPMC10645105 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature