Diving deep into fish bornaviruses: Uncovering hidden diversity and transcriptional strategies through comprehensive data mining.

ABSTRACT: Recently, we discovered two novel orthobornaviruses in colubrid and viperid snakes using an in silico data-mining approach. Here, we present the results of a screening of more than 100,000 nucleic acid sequence datasets of fish samples from the Sequence Read Archive (SRA) for potential bornaviral sequences. We discovered the potentially complete genomes of seven bornavirids in datasets from osteichthyans and chondrichthyans. Four of these are likely to represent novel species within the genus Cultervirus, and we propose that one genome represents a novel genus within the family of Bornaviridae. Specifically, we identified sequences of Wǔhàn sharpbelly bornavirus in sequence data from the widely used grass carp liver and kidney cell lines L8824 and CIK, respectively. A

SUBMITTER: Eshak MIY 

PROVIDER: S-EPMC10645145 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature