Phylogenomics of Leptospira santarosai, a prevalent pathogenic species in the Americas.

ABSTRACT:

Background

Leptospirosis is a complex zoonotic disease mostly caused by a group of eight pathogenic species (L. interrogans, L. borgpetersenii, L. kirschneri, L. mayottensis, L. noguchii, L. santarosai, L. weilii, L. alexanderi), with a wide spectrum of animal reservoirs and patient outcomes. Leptospira interrogans is considered as the leading causative agent of leptospirosis worldwide and it is the most studied species. However, the genomic features and phylogeography of other Leptospira pathogenic species remain to be determined.

Methodology/principal findings

Here we investigated the genome diversity of the main pathogenic Leptospira species based on a collection of 914 genomes from strains isolated around the world. Genome analyses revealed species-specific genome size a

SUBMITTER: Chinchilla D 

PROVIDER: S-EPMC10645364 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature