The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care.

ABSTRACT: Polygenic risk scores (PRSs) hold promise for disease risk assessment and prevention. The Genomic Medicine at Veterans Affairs (GenoVA) Study is addressing three main challenges to the clinical implementation of PRSs in preventive care: defining and determining their clinical utility, implementing them in time-constrained primary care settings, and countering their potential to exacerbate healthcare disparities. The study processes used to test patients, report their PRS results to them and their primary care providers (PCPs), and promote the use of those results in clinical decision-making are modeled on common practices in primary care. The following diseases were chosen for their prevalence and familiarity to PCPs: coronary artery disease; type 2 diabetes; atrial fibrillation; and breas

SUBMITTER: Vassy JL 

PROVIDER: S-EPMC10645559 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature