Non-oral continuous drug delivery based therapies and sleep dysfunction in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Tall P
PROVIDER: S-EPMC10645607 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
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Non-oral continuous drug delivery based therapies and sleep dysfunction in Parkinson's disease.
Tall P P Qamar M A MA Batzu L L Leta V V Falup-Pecurariu C C Ray Chaudhuri K K
Journal of neural transmission (Vienna, Austria : 1996) 20230501 11
Continuous drug delivery (CDD) has emerged as a feasible and pragmatic therapeutic option for dopamine replacement therapy in advanced Parkinson's disease (PD). CDD aims to mimic the physiological tonic dopamine release from striatal dopaminergic neurons and thus reduces the severity and duration of motor and non-motor fluctuations partly related to pulsatile levodopa stimulation. Non-motor symptoms and fluctuations are ubiquitous in PD and include sleep dysfunction, a problem that occurs in ove ...[more]
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