Identification of a novel five ferroptosis-related gene signature as a promising prognostic model for breast cancer.

ABSTRACT:

Background

Breast cancer (BCa) is a major challenge for women's health worldwide. Ferroptosis is closely related to tumorigenesis and cancer progression. However, the prognostic value of ferroptosis-related genes in BCa remains unclear, and more accurate prognostic models are urgently needed.

Methods

Gene expression profiles and clinical information of BCa patients were collected from public databases. LASSO and multivariate Cox regression analysis were utilized to construct the prognostic gene signature. Kaplan-Meier plotter, receiver operating characteristic (ROC) curves, and nomogram were used to validate the prognostic value of the gene signature. Gene set enrichment analysis was performed to explore the molecular functions and signaling pathways.

Results

Differen

SUBMITTER: Cheng TC 

PROVIDER: S-EPMC10645672 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature