Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β.

ABSTRACT: The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy. The phosphatidylinositol transfer protein alpha/beta isoform (PITPα/β) has been reported to play an essential role in integrating phosphoinositide trafficking and lipid metabolism in diverse cellular processes but remains unexplored as a potential target for cancer treatment. Herein, data analysis of clinical cancer samples revealed that PITPα/β expression is closely correlated with the poor prognosis. Target identification by chemical proteomic methods revealed that microcolin H, a naturally occurring marine lipopeptide, directly binds PITPα/β and displays antiproliferative activity on different types of tumour cell lines. Furthermore, we identified that microc

SUBMITTER: Yang H 

PROVIDER: S-EPMC10645841 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature