Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide.

ABSTRACT: The acquisition of antimicrobial resistance (AR) genes has rendered important pathogens nearly or fully unresponsive to antibiotics. It has been suggested that pathogens acquire AR traits from the gut microbiota, which collectively serve as a global reservoir for AR genes conferring resistance to all classes of antibiotics. However, only a subset of AR genes confers resistance to clinically relevant antibiotics, and, although these AR gene profiles are well-characterized for common pathogens, less is known about their taxonomic associations and transfer potential within diverse members of the gut microbiota. We examined a collection of 14,850 human metagenomes and 1666 environmental metagenomes from 33 countries, in addition to nearly 600,000 isolate genomes, to gain insight into the globa

SUBMITTER: Diebold PJ 

PROVIDER: S-EPMC10645880 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature