The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice.

ABSTRACT: Memory reconsolidation refers to the process by which the consolidated memory was restored after reactivation (RA). Memory trace becomes labile after reactivation and inhibition of memory reconsolidation may disrupt or update the original memory trace, which provided a new strategy for the treatment of several psychiatric diseases, such as drug addiction and post-traumatic stress disorder. Fat mass and obesity-associated gene (FTO) is a novel demethylase of N6-methyladenosine (m6A) and it has been intensively involved in learning and memory. However, the role of FTO in memory reconsolidation has not been determined. In the present study, the function of FTO in memory reconsolidation was investigated in the novel object recognition (NOR) model in mice. The results showed that RA of NOR memo

SUBMITTER: Chang R 

PROVIDER: S-EPMC10645923 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature