A spectroscopic liquid biopsy for the earlier detection of multiple cancer types.

ABSTRACT:

Background

A rapid, low-cost blood test that can be applied to reliably detect multiple different cancer types would be transformational.

Methods

In this large-scale discovery study (n = 2092 patients) we applied the Dxcover® Cancer Liquid Biopsy to examine eight different cancers. The test uses Fourier transform infrared (FTIR) spectroscopy and machine-learning algorithms to detect cancer.

Results

Area under the receiver operating characteristic curve (ROC) values were calculated for eight cancer types versus symptomatic non-cancer controls: brain (0.90), breast (0.76), colorectal (0.91), kidney (0.91), lung (0.91), ovarian (0.86), pancreatic (0.84) and prostate (0.86). We assessed the test performance when all eight cancer types were pooled to classify 'any cancer'

SUBMITTER: Cameron JM 

PROVIDER: S-EPMC10645969 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature