AuNP-Loaded Electrospinning Membrane Cooperated with CDs for Periodontal Tissue Engineering.

ABSTRACT:

Background

Guided bone regeneration (GBR) is commonly used to regenerate periodontal tissue. However, the bone inductivity and antibacterial properties of the GBR membranes currently in use are severely limited. This issue can be resolved by loading growth factors and antibiotics. Bioactive substitutes, such as Au nanoparticles (AuNPs) and carbon quantum dots (CDs), were proposed to prevent the denaturation of osteogenic growth factors and the induction of antibacterial drug resistance.

Methods

Ornidazole was initially used as the raw material to prepare the CDs, followed by the incorporation of an optimal ratio of nanoparticles to produce the electrospun membrane doped with AuNPs and novel traceable antibacterial CDs. The morphology of the membrane was characterized. The ad

SUBMITTER: Wang J 

PROVIDER: S-EPMC10646012 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature