Gut inflammation associated with age and Alzheimer's disease pathology: a human cohort study.

ABSTRACT: Age-related disease may be mediated by low levels of chronic inflammation ("inflammaging"). Recent work suggests that gut microbes can contribute to inflammation via degradation of the intestinal barrier. While aging and age-related diseases including Alzheimer's disease (AD) are linked to altered microbiome composition and higher levels of gut microbial components in systemic circulation, the role of intestinal inflammation remains unclear. To investigate whether greater gut inflammation is associated with advanced age and AD pathology, we assessed fecal samples from older adults to measure calprotectin, an established marker of intestinal inflammation which is elevated in diseases of gut barrier integrity. Multiple regression with maximum likelihood estimation and Satorra-Bentler correct

SUBMITTER: Heston MB 

PROVIDER: S-EPMC10646035 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature