Bioinformatics analysis of multi-epitope peptide vaccines against Hepatitis C virus: a molecular docking study.

ABSTRACT:

Background

Hepatitis C Virus (HCV) infection is one of the causal agents of liver disease burden. Six multiple antigenic peptides were synthesized including (P315, P412, and P517) plus (P1771, P2121, and P2941) to induce humoral and cellular responses, respectively against HCV infection.

Aim

This paper aimed to employ computational tools to evaluate the efficacy of each peptide individually and to determine the most effective one for better vaccine development and/or immunotherapy.

Methods

VaxiJen web and AllerTOP servers were used for antigenicity and allergenicity prediction, respectively. The ToxinPred web server was used to investigate the peptide toxicity. Each peptide was docked with its corresponding receptors.

Results

No peptides were expected to be tox

SUBMITTER: Muhammad AM 

PROVIDER: S-EPMC10646107 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature