Post-stroke depression: epigenetic and epitranscriptomic modifications and their interplay with gut microbiota.

ABSTRACT: Epigenetic and epitranscriptomic modifications that regulate physiological processes of an organism at the DNA and RNA levels, respectively, are novel therapeutic candidates for various neurological diseases. Gut microbiota and its metabolites are known to modulate DNA methylation and histone modifications (epigenetics), as well as RNA methylation especially N6-methyladenosine (epitranscriptomics). As gut microbiota as well as these modifications are highly dynamic across the lifespan of an organism, they are implicated in the pathogenesis of stroke and depression. The lack of specific therapeutic interventions for managing post-stroke depression emphasizes the need to identify novel molecular targets. This review highlights the interaction between the gut microbiota and epigenetic/epitran

SUBMITTER: Jeong S 

PROVIDER: S-EPMC10646155 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature