Walking energetics and white matter hyperintensities in mid-to-late adulthood.

ABSTRACT:

Introduction

White matter hyperintensities (WMHs) increase with age and contribute to cognitive and motor function decline. Energy costs for mobility worsen with age, as the energetic cost of walking increases and energetic capacity declines. We examined the cross-sectional associations of multiple measures of walking energetics with WMHs in mid- to late-aged adults.

Methods

A total of 601 cognitively unimpaired adults (mean age 66.9 ± 15.3 years, 54% women) underwent brain magnetic resonance imaging scans and completed standardized slow- and peak-paced walking assessments with metabolic measurement (V̇O₂). T1-weighted scans and fluid-attenuated inversion recovery images were used to quantify WMHs. Separate multivariable linear regression models examined associati

SUBMITTER: Dougherty RJ 

PROVIDER: S-EPMC10646278 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature