Autologous CIK cells combined with chemotherapy as the first-line treatment for locally advanced or metastatic gastric cancer is safe and feasible.

ABSTRACT:

Aim

To evaluate the safety and initial efficacy of autologous cytokine-induced killer (CIK) cells combined with S-1+oxaliplatin (SOX) as the first-line treatment for locally advanced or metastatic gastric cancer (GC).

Materials and methods

In this two-arm, single-center exploratory trial, patients with locally advanced or metastatic GC were randomly assigned (1:1) to receive autologous CIK cells in combination with SOX (CIK-SOX) or SOX alone. The primary endpoint was the incidence of adverse events (AEs). Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and disease control rate (DCR) served as the secondary endpoints.

Results

Fifty-nine patients were enrolled in the study between November 20, 2014 and September 6, 2017. A total of

SUBMITTER: Ma X 

PROVIDER: S-EPMC10646377 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature