A prognostic model for tumor recurrence and progression after meningioma surgery: preselection for further molecular work-up.

ABSTRACT:

Purpose

The selection of patients for further therapy after meningioma surgery remains a challenge. Progress has been made in this setting in selecting patients that are more likely to have an aggressive disease course by using molecular tests such as gene panel sequencing and DNA methylation profiling. The aim of this study was to create a preselection tool warranting further molecular work-up.

Methods

All patients undergoing surgery for resection or biopsy of a cranial meningioma from January 2013 until December 2018 at the University Hospital Zurich with available tumor histology were included. Various prospectively collected clinical, radiological, histological and immunohistochemical variables were analyzed and used to train a logistic regression model to predict tumor

SUBMITTER: Padevit L 

PROVIDER: S-EPMC10646388 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature