Secretagogin as a marker to distinguish between different neuron types in human frontal and temporal cortex.

ABSTRACT: The principal aim of the present work was to chemically characterize the population of neurons labeled for the calcium binding protein secretagogin (SCGN) in the human frontal and temporal cortices (Brodmann's area 10 and 21, respectively). Both cortical regions are involved in many high cognitive functions that are especially well developed (or unique) in humans, but with different functional roles. The pattern of SCGN immunostaining was rather similar in BA10 and BA21, with all the labeled neurons displaying a non-pyramidal morphology (interneurons). Although SCGN cells were present throughout all layers, they were more frequently observed in layers II, III and IV, whereas in layer I they were found only occasionally. We examined the degree of colocalization of SCGN with parvalbumin (PV)

SUBMITTER: Tapia-Gonzalez S 

PROVIDER: S-EPMC10646422 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature