Causal effects of nonalcoholic fatty liver disease on cerebral cortical structure: a Mendelian randomization analysis.

ABSTRACT:

Background

Previous studies have highlighted changes in the cerebral cortical structure and cognitive function among nonalcoholic fatty liver disease (NAFLD) patients. However, the impact of NAFLD on cerebral cortical structure and specific affected brain regions remains unclear. Therefore, we aimed to explore the potential causal relationship between NAFLD and cerebral cortical structure.

Methods

We conducted a Mendelian randomization (MR) study using genetic predictors of alanine aminotransferase (ALT), NAFLD, and percent liver fat (PLF) and combined them with genome-wide association study (GWAS) summary statistics from the ENIGMA Consortium. Several methods were used to assess the effect of NAFLD on full cortex and specific brain regions, along with sensitivity analyses.<

SUBMITTER: Mai Z 

PROVIDER: S-EPMC10646496 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature