Correlation between diabetic retinopathy and diabetic nephropathy: a two-sample Mendelian randomization study.

ABSTRACT:

Rationale & objective

A causal relationship concerning diabetic retinopathy (DR) and diabetic nephropathy (DN) has been studied in many epidemiological observational studies. We conducted a two-sample mendelian randomization study from the perspective of genetics to assess these associations.

Methods

20 independent single nucleotide polymorphisms (SNPs) associated with diabetic retinopathy were selected from the FinnGen consortium. Summary-level data for diabetic nephropathy were obtained from the publicly available genome-wide association studies (GWAS) database, FinnGen and CKDGen consortium. Inverse variance weighted (IVW) was selected as the primary analysis. MR-Egger, weighted median (WM), simple mode and weighted mode were used as complementary methods to examine causa

SUBMITTER: Fang J 

PROVIDER: S-EPMC10646564 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature