Efficacy of low-dose lung radiotherapy in the management of COVID-19 patients: a randomised, open-label study.

ABSTRACT:

Objective

Evaluate role of low-dose radiotherapy (LDRT) in COVID-19 pneumonia.

Methods

Sixty-five patients 40 years or older tested positive for COVID-19 reverse transcriptase-polymerase chain reaction with mild to moderate acute respiratory distress syndrome (ARDS), were randomised 1:1, from 4 June 2021, to either best standard of care (control arm) according to the Indian Council of Medical Research guidelines or a single dose of LDRT (LDRT-0.5Gy) to both lungs along with best standard of care (experimental arm). The primary outcome was either progression to severe disease (PaO2/FiO2 ratio <100 mmHg) within 28 days of randomisation or all-cause mortality at 28 days. If the primary outcome could have been prevented, it was considered "favourable"; if not, it was considered

SUBMITTER: Dinakar K 

PROVIDER: S-EPMC10646638 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature