Prospective inter- and intra-tracer repeatability analysis of radiomics features in [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]F-PSMA-1007 PET scans in metastatic prostate cancer.

ABSTRACT:

Objective

This study aimed to quantify both the intra- and intertracer repeatability of lesion-level radiomics features in [⁶⁸Ga]Ga-prostate-specific membrane antigen (PSMA)-11 and [¹⁸F]F-PSMA-1007 positron emission tomography (PET) scans.

Methods

Eighteen patients with metastatic prostate cancer (mPCa) were prospectively recruited for the study and randomised to one of three test-retest groups: (i) intratracer [⁶⁸Ga]Ga-PSMA-11 PET, (ii) intratracer [¹⁸F]F-PSMA-1007 PET or (iii) intertracer between [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]F-PSMA-1007 PET. Four conventional PET metrics (standardised uptake value (SUV)_max, SUV_mean, SUV_total and volume) and 107 radiomics features were extracted

SUBMITTER: Kendrick J 

PROVIDER: S-EPMC10646662 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature