Hyper high haemoglobin content in red blood cells and erythropoietic transitions postnatally in infants of 22 to 26 weeks' gestation: a prospective cohort study.

ABSTRACT:

Objective

Blood cell populations, including red blood cells (RBC) unique to the extremely preterm (EPT) infant, are potentially lost due to frequent clinical blood sampling during neonatal intensive care. Currently, neonatal RBC population heterogeneity is not described by measurement of total haemoglobin or haematocrit. We therefore aimed to describe a subpopulation of large RBCs with hyper high haemoglobin content, >49 pg (Hyper-He) following EPT birth.

Design

Prospective observational cohort study.

Setting

Two Swedish study centres.

Participants

Infants (n=62) born between gestational weeks 22⁺⁰ to 26⁺⁶.

Methods

Prospective data (n=280) were collected from March 2020 to September 2022 as part of an ongoing randomised controlled t

SUBMITTER: Larsson SM 

PROVIDER: S-EPMC10646872 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature