Poly(2-oxazoline)/saRNA Polyplexes for Targeted and Nonviral Gene Delivery.

ABSTRACT: RNA delivery has been demonstrated to be a potent method of vaccine delivery, as demonstrated by the recent success of the COVID-19 vaccines. Polymers have been shown to be effective vehicles for RNA delivery, with poly(ethylene imine) (PEI) being the current gold standard for delivery. Nonetheless, PEI has toxicity concerns, and so finding alternatives is desirable. Poly(2-oxazoline)s are a promising alternative to PEI, as they are generally biocompatible and offer a high degree of control over the polymer structure. Here, we have synthesized an ionizable primary amine 2-oxazoline and combined it with a double bond containing oxazoline to synthesize a small library of charged statistical and block copolymers. The pendant double bonds were reacted further to decorate the polymers with gluc

SUBMITTER: Hayes G 

PROVIDER: S-EPMC10646937 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature